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Description:That damn neurotransmitter is everywhere. Abundant evidence points to dopamine as the key neurotransmitter involved in stimulating orgasm in humans. Thus, administration of the dopamine precursor L-dopa, dopaminergic agonists e. Conversely, administration of antipsychotics impair orgasm, by blocking postsynaptic dopamine receptors see Komisaruk et al. Dopamine-synthesising neurons that originate in the lower brainstem specifically the ventral tegmental area are activated during ejaculation in men, as measured by PET imaging Holstege et al.

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